Coping with Digestive Side Effects from ROS1+ Targeted Therapy

Digestive issues are among the most common side effects experienced by people taking ROS1-targeted tyrosine kinase inhibitors (TKIs). These may include nausea, vomiting, diarrhea, constipation, indigestion, and reflux. While they can be disruptive, many patients find relief through small adjustments to their daily routines. This guide offers practical tips and insights from the ROS1+ community and healthcare providers.

Nausea and vomiting

• Take your medication with food: A full meal can help reduce nausea. Some people prefer starchy foods; others feel better after eating protein.

• Stay upright after dosing: Sit or stand for at least an hour after taking your TKI to prevent reflux and vomiting.

• Hydrate regularly: Drinking water throughout the day supports digestion and can ease symptoms.

• Talk to your care team: Prescription anti-nausea medications may help if over-the-counter strategies aren’t enough.

Diarrhea

• Identify trigger foods: Keep a food diary to pinpoint meals that may be contributing to symptoms.

• Use over-the-counter remedies: Loperamide (Imodium) can be effective for managing episodes.

• Replenish fluids: Diarrhea can cause dehydration, so staying hydrated with water and electrolyte solutions is important.

Constipation

• Increase fiber: Add high-fiber foods such as bran, vegetables, and legumes to your diet.

• Stay hydrated: Fiber needs water to work properly, so aim to drink regularly throughout the day.

• Consider gentle aids: Stool softeners or polyethylene glycol (Miralax) can provide relief if needed.

Reflux and esophageal burning

• Take with water and food: Swallow your TKI with a full glass of water and follow it with a small bite of food to help move the pill through the esophagus.

• Stay upright after taking your medication: This can reduce the chance of reflux or discomfort.

Indigestion and stomach discomfort

• Avoid an empty stomach: Taking your TKI with food can help buffer the stomach lining and ease irritation.

• Eat gently: Soft, bland foods may be easier to tolerate when symptoms are present.

When to contact your medical team

You should notify your care team if you experience:

• Ongoing nausea, vomiting, or diarrhea

• Difficulty swallowing or a burning sensation in the throat or chest

• Signs of dehydration or weight loss

• New or worsening digestive symptoms

Your provider may recommend additional treatments or adjust your medication to help manage side effects more effectively.

Digestive issues can affect your comfort, nutrition, and quality of life, but there are many strategies that can help. From adjusting meal timing to using over-the-counter support, small changes can make a big difference. If symptoms persist, your medical team can work with you to find the right approach. You're not alone—and with the right tools and support, side effects can become more manageable.