NCCN Guidelines recommend lorlatinib for second-line ROS1+ NSCLC

Updated: Feb 15

The new National Comprehensive Cancer Network (NCCN) Guidelines for non-small cell lung cancer (NSCLC) added lorlatinib as a ROS1 treatment option, after progression on crizotinib or ceritinib. This means most insurance should start covering lorlatinib for ROS1.


NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Non-Small Cell Lung Cancer (Version 2.2019) (subscription required, but it’s free)

  • Subsequent Therapy for ROS1 Rearrangement-Positive Metastatic NSCLC (NSCL-24)

  • Lorlatinib (category 2A) added as a treatment option, after progression on crizotinib or ceritinib.


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